Tuesday, June 14, 2016

Depakote for migraines

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From People On Emgality. Does anyone take Topamax for migraines? It is taken by mouth as preventative therapy to reduce migraine frequency.


Those with frequent migraine attacks or migraine who do not respond to acute treatment should consider preventive medications. Seniors may require a lower dosage. If you suffer from migraines , no one needs to suggest that you bone up on migraine medications or therapies. You are no doubt well-versed in several effective drugs on the market to help stop a migraine.


But what about medications that help to prevent a migraine in the first place? Sodium valproate is an established agent for migraine prophylaxis and appears effective in aborting glyceryl trinitrate–induced migraine attacks.

Although the mechanism of action of valproate in migraine is not certain, valproate potentiates gamma-aminobutyric acid (GABA) 7and decreases the activation in the trigeminal nucleus. It also caused non-alcoholic steatoid hepatitis (aka extreme fatty liver). I also now have Type Diabetes. My body was shutting down because of Depakote.


This is a drug that we consider to be one of the best headache medications if you are having 2-headaches per week or more than one disabling headache per month. Repeat a 2nd IV dose within hours. Patients use it to treat several illnesses. If that works then proceed to oral dosing as above. If it doesn’t then plan for additional therapy – likely DHE and inpatient admission.


Oral divalproex sodium (VPA) is utilized widely as a preventive for migraine and for chronic daily headache 2. Depakote and headache actually makes for a good combination. Off-label uses include alcohol dependency, to quell impulsivity and aggressive behavior. She went to a neurologist who put her on Topamax at the max dose and she still had migraines to so severe she would lose time, like a mini seizure. Doctors prescribe it to treat seizure disorders and to prevent migraine headaches. People also use it to manage the manic phase of bipolar disorder.


I had no side effects at all. It did not however help my migraines. First line abortive therapies for ER patients.


IV Anti-emetics Prochlorperazine (Compazine) Metoclopramide (Reglan) Promethazine (Phenergan) Steroids Methylprednisolone (Solumedrol) gram IV once.

Divalproex sodium does not relieve acute migraine headaches. Take other medications as directed by your doctor for acute attacks. The bottom line is, you pick side effects.


Migraine Headaches Connected to Hormones, Lifestyle.

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