Propofol treatment for depression

Is ketamine the future clozapine for depression? Can ketamine infusions really help depression? Does fentanyl cause depression? Is Hypnotherapy an effective treatment for depression?

This open-label trial was designed to collect preliminary data regarding the feasibility, tolerability, and efficacy of deep propofol anesthesia for treatment -resistant depression.

Self-rated depression scores were compared with a group of patients who received electroconvulsive therapy. The drug could become a viable treatment for depression , but more research is needed. We hypothesized that propofol, a unique general anesthetic that engages N-methyl-D-aspartate and gamma-aminobutyric acid receptors, has antidepressant properties.

Self-reported depressive symptoms were measured with the QIDS-SR just prior to each propofol treatment session. Because the QIDS-SR was collected from ECT patients in the same way during routine clinical care, we were able to compare depression ratings between propofol participants (n=10) and an ECT comparison group (n=20). Secon propofol is a potent anticonvulsant that may worsen the quality of the ECT induced seizures.

A recent open-label trial compared ketamine to propofol for anesthesia during ECT and demonstrated a significant improvement of depression in the ketamine arm.

Therefore, Study will be an open-label trial to provide preliminary data that propofol, an intravenous anesthetic with a favorable safety profile, administered for treatment sessions at levels to induce burst suppression, also is effective in producing depression remission in or more of the pilot sample of depressed patients. Propofol is an intravenous (IV) sedative-hypnotic agent that can be used for initiation and maintenance of Monitored Anesthesia Care sedation, combined sedation and regional anesthesia, induction of general anesthesia, maintenance of general anesthesia, and intensive care unit sedation of intubate mechanically ventilated patients. It is not recommended for children, but for adults only. The medication, according to RxList.

The long term outcomes of this. Both as to whether she needs repeated treatments, and to whether it(the treatment with Propofol) has any long lasting adverse side effects. Of the six who responded to the propofol treatments, five saw the continue for at least three months, Mickey said. Propofol Injectable Emulsion is not recommended for use in nursing mothers because Propofol Injectable Emulsion has been reported to be. Taking other medicines that make you sleepy or slow your breathing can worsen these effects.

After you have been treated with propofol , ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression , or seizures (especially valproic acid). Midazolam is a benzodiazepine and Propofol is an I. Brand names for midazolam include Versed. Side effects of midazolam and Propofol that are similar include slow heart rate, rash, and injection site pain.

Anesthetic drug propofol shows promise in the treatment of medication-resistant depression in a new pilot study - The preliminary research suggests that propofol may trigger rapi durable antidepressant effects, similar to the response to ECT, but without ECT’s side effects. Propofol is used to reduce anxiety and tension, as well as to promote relaxation and sleep. Depression will be evaluated before and after treatment.

Propofol is also used to promote a loss of consciousness or loss of awareness for short diagnostic tests and surgical procedures. Short-term effects of Propofol include mild euphoria, hallucinations, and disinhibition. Participants with treatment -resistant depression will receive propofol at two different doses in a blinded randomized controlled crossover pilot trial. We hypothesize that depressive symptoms will improve to a greater degree and more quickly with high-dose propofol compared to low-dose propofol. The researchers do not know how propofol supposedly “works” for depression , but theorize it “may be triggering the brain to reorganize itself” or “coaxing the brain into getting unstuck from this ba depressed state that it’s in.

We’ve heard of similar, unproven theories in relation to antidepressants and electroshock treatment.